ProGR3® Innovation: a unique longevity active ingredient

Nicolas Lévy has dedicated his career for over 30 years to patients with rare genetic diseases, notably progeria. His path crossed that of the Perrin Family at the beginning of the Beau Domaine project. The family was seeking true scientific expertise to understand the biological mechanisms of aging. Sharing this desire to combine naturality with scientific expertise, they chose to draw upon Professor Lévy's research, finding inspiration in the treatment avenues for this rare disease to reinvent anti-aging skincare.

Progeria is an extremely rare genetic disease characterized by premature and accelerated aging in children. This pathology alters growth, bones, and the vascular system, leading to very early aging that impacts almost all organs except the brain. At the root of this disorder lies a senescence mechanism that we all share, but at very different levels: the accumulation of a toxic protein, progerin, within the cell nuclei. Unlike natural aging, where cells only begin to produce this protein from about the age of 24, children with progeria synthesize it in massive amounts right from birth. This process, which normally takes place over several decades, is immediate here and causes an accelerated degradation of the body.

Drawing on his medical research, Professor Lévy designed an unprecedented anti-aging cosmetic active ingredient, marking a true revolution on the market. To naturally and effectively target and reduce progerin's toxicity, he and his team selected three plant extracts that make up the unprecedented ProGR3® formula: resveratrol from the Perrin Family's vine shoots, apigenin extracted from chamomile flowers, and catechin from green tea leaves. To validate this innovation, rigorous preclinical tests were conducted, demonstrating in an unprecedented way the synergy of these extracts and their ability to neutralize progerin's toxicity.

Resveratrol, a key ingredient in the ProGR3® formulation, comes from the Perrin Family's vine shoots, cultivated using organic and biodynamic agriculture since the 1970s. The production of this ingredient follows a rigorous protocol, combining scientific standards with the preservation of the ecosystem. The shoots harvested from the vines are dried, analyzed in the laboratory, and then subjected to an eco-extraction and green purification process. This method isolates an extract certified by COSMOS (the organic standard for cosmetics), guaranteeing optimal purity and concentration of resveratrol.